What is creatinine in the blood, and why its increase is associated with kidney pathology

The level of creatinine in the blood is able to talk about the condition of the urinary system of a woman. Its amount can be found during a biochemical blood test. Blood levels of creatinine may decrease with age. The value of the indicator can be influenced by a woman’s lifestyle and her nutrition.

And now let's dwell on this in more detail.

What is blood creatinine in a woman?

Creatinine is a protein metabolism product. It appears as a result of the breakdown of creatine, a substance that saturates a person’s muscles with energy. Before creatinine develops, the component goes a long way throughout the body. It begins in the renal parenchyma. Methylation of the substance is carried out in the liver. Creatine is then delivered to the muscles where it breaks down. The result is the energy needed to contract.

The residual decomposition product is creatinine. It enters the bloodstream. Subsequently, the excretion of the substance is carried out through the kidneys. It leaves the body with urine.

The process of creating and removing creatinine from the body is carried out continuously. Therefore, its amount in human blood almost never changes. The level of the substance is quite small. The fact is that it is toxic. For this reason, it is so important to monitor the concentration of creatinine in human blood.

Biochemical standards

Below is a table of creatinine norms in women by age, as well as in men. It will help assess the presence and degree of dysfunction of the organs of the excretory system.

Table - Norms of creatinine by age and gender

Gender and ageCreatinine Level μmol / L
Breasts up to 1 year old18-36
Children under 14 years old25-65
Girls from 15 years old and women52-98
Teenage Boys, Men82-116

Blood creatinine - what is it

Creatinine belongs to the group of low molecular weight nitrogenous substances. In fact, it is an anhydride (chemical compound) of creatine (nitrogen-containing carboxylic acid), which provides the muscle tissue of the body with the necessary energy.

It is formed as a result of metabolic processes in the structure of muscle tissues by cleavage of enzyme proteins (dephosphorylation) and non-enzymatic dehydration (decomposition) of nitrogen-containing carboxylic acid.

The “energetic raw material” necessary for the tissues is produced by the pancreas, kidneys and liver.

After its formation, it is delivered through the bloodstream to the cellular structure of muscle tissue. Here, as a result of a reaction with an enzyme, kinases are converted into the form of creatine phosphate or phosphocreatine. Joining a phosphate acid process gives a reaction powerful energy for contractile muscle function.

It is in the process of energy formation that creatine is temporarily converted to creatinine. Subsequently, the substance is excreted from the body with urine.

Our body stably produces creatinine and creatine in a certain amount, maintaining the necessary balance. Up to 2% of creatine is converted to creatinine daily. Its value in the body is constant, since the muscle mass of a person is virtually unchanged.

Creatinine levels may vary depending on muscle mass, gender and age of the patient. Almost all energetic substance is produced due to glomerular filtration in the kidneys, only 15% secrete renal tubules.

Since the substance is excreted from the body through the urinary system, then creatinine clearance (the volume of blood passed through the kidneys and purified from the substance in 1 minute) in urine, one can judge the effectiveness of the glomerular filtration processes and the health of the kidneys themselves.

Therefore, the concentration of creatinine in blood plasma, not going beyond a certain norm, is a good indicator of the functional viability of the kidneys, or a sensitive indicator of their pathologies.

It is interesting. Since fish and meat are considered the richest creatinine-rich foods, many "experts" believe that providing muscle tissue with the necessary energy is possible only through a balanced diet.

Moreover, without realizing that for a normal “loading” of creatinine into the body, it will be necessary to include up to 5 kg in the daily diet, among other products, during the week. meat in its purest form.

What is creatinine in a biochemical blood test?

Creatinine secretion occurs in the glomeruli of the renal apparatus, and only 15% is excreted by the renal tubules. Based on this: the level of the substance is within acceptable values ​​during normal kidney function. A decrease in glomerular filtration naturally leads to its accumulation in the blood, and not excretion from the body with urine.

The required amount of substance is determined based on the total mass of a person and his physical activity. Which leads to the fact that the norm of creatinine in the blood test for men, women and children is significantly different.

In addition to gender and weight, the age of the patient also affects the indicator. This allows us to attribute the biochemical analysis of blood to creatinine to exclusively primary diagnostic methods. It was noted that the criterion is characterized by a greater degree of sensitivity to kidney pathologies than urea.

Creatinine: general information

Creatinine is formed in muscle tissue as a result of the complex process of protein conversion - the mechanism of energy metabolism.

Creatinine is a toxic breakdown product. Once in the blood, it must be excreted in the urine in a timely manner, changes in creatinine (in either direction) signal a violation of the kidneys.

Creatinine level directly depends on muscle volume, therefore, its indicators in men are usually higher than in women, in athletes - higher than in those who do not engage in sports, etc.

What is creatinine and what is it responsible for

Creatinine (in the blood, the norm of a non-protein compound depends on many factors) is one of the final substances in the exchange of simple and complex proteins. With proper functioning of the body, it is excreted with urine. The creatinine compound is formed from creatine protein, which is the basis of activity for skeletal muscle in the body.

In this complex process of chemical transformations, the protein creatine is stored in a new form - phosphocreatine, which is the energy to reduce muscle fibers in the body.

At the same time, he gives his energy to the body, and he is divided into the final metabolic products - creatinine, water and phosphates. Thus, a non-protein compound is the final product that takes part in the energy metabolism of the body.

The norm of creatinine in women

The norm is considered if the woman's blood contains 50-98 μmol / l creatinine. This is the average value of the indicator. In men, the amount of creatinine in the blood is slightly higher. This is due to the large amount of muscle mass. If a woman has a full body, the value of the indicator will also increase.

How is the study

How to pass an analysis on creatinine and prepare for it, will tell the attending physician, directing the study, or laboratory staff. In most clinics and diagnostic centers, blood sampling for creatinine is by appointment. This is due to the fact that it is necessary to prepare for the study. Recommendations include:

  • refusal of physical activity - two days before the study,
  • refusal of certain products - alcohol, strong tea and coffee, proteins, meat and all medicines 24 hours before analysis,
  • refusal to eat - do not eat ten hours before a visit to the laboratory, it is allowed to drink clean still water,
  • relaxation before the procedure - sit for 15 minutes to get a more reliable result.

Normal creatinine in women

The norm of creatinine in children and adolescents of the same age is the same for boys and girls.

Age yearsThe rate of creatinine, micromol / l
Newborns up to 1 year old30-49
1-632-53
6-1135-61
11-1547-71

In adults, normal rates depend on gender: for women, they are lower than for men.

How is the value of the indicator determined?

To determine the level of creatinine in the blood of a woman after 50 years, it is necessary to undergo a biochemical analysis. For this, biomaterial is taken from the ulnar vein. The study requires about 5-10 milliliters of blood. The fence is carried out in a control room with strict adherence to the rules of asepsis and antiseptics.

After sampling, the blood settles in the test tube for some time. As a result, a clot forms and the serum is separated. Biological fluid is introduced into a special biochemical analyzer. With its help, the concentration of creatinine is determined. The action is performed automatically.

Creatinine can be tested as a preventative measure. After 50 years, the action is recommended to be performed at least once a year. However, the patient may be referred for examination. Indications for this are:

  • arterial hypertension
  • shock state
  • blood poisoning,
  • renal failure.

An analysis is given before the dialysis procedure and taking kidney samples. Suspicion of a disease of the urinary system can also be the reason for the appointment of a study.

The result of the analysis is influenced by a large number of factors. To ensure that data is not distorted, a number of rules must be followed. A woman should remember the following:

  1. Blood sampling is performed strictly on an empty stomach. The procedure is performed in the morning. After sleep, a woman can drink unsweetened tea or still mineral water.
  2. On the day on which the biochemical blood test is scheduled, it is necessary to abandon physical and emotional stress. They can affect creatinine levels. Experts say that accurate data can be obtained in case of refusal of loads several days before the analysis. Smoking is also prohibited.
  3. It is recommended to rest for 15-20 minutes before blood sampling. To do this, sit down and do nothing.
  4. It is also not recommended to use drugs before biochemical analysis. If the termination of their reception is not possible, it is necessary to inform the laboratory assistant.
  5. Before the study, do not abuse protein foods. A day before the analysis, you should make a menu of the simplest and easiest dishes.
  6. Refusal of alcohol should be carried out three days before a visit to the handling room.

What is the analysis done for?

A physician, nephrologist, gynecologist, urologist or infectious disease specialist can send a patient for examination. A biochemical blood test for creatinine is performed to:

  • detection of renal pathologies,
  • muscle damage assessment
  • determining the therapeutic efficacy of selected renal treatments. Especially relevant if the patient has diabetes mellitus or chronic renal failure,
  • calculation of creatinine clearance rate - an analysis to evaluate the effectiveness of renal filtration of small molecules,
  • diagnostics of glomerular filtration rate.

Physiological causes of abnormalities

Creatinine levels are influenced by a large number of factors that must be taken into account. If the value of the indicator deviates from the norm, the following characteristics of the patient should be taken into account:

  • height and weight,
  • physical activity
  • daily diet
  • compliance with the standards for the analysis,
  • age,
  • the presence of pregnancy.

Deviation from the norm can cause a diet. The exclusion of protein from the diet causes a decrease in creatinine. A low level of a substance reduces the amount of its decay products. Accordingly, creatinine levels are also reduced.

The amount of substance in the blood of a woman decreases during pregnancy. This is due to an increase in total blood volume. In particular, creatinine falls in the first and second trimester. In this case, a clearance analysis may show that creatinine is elevated.

Reducing the concentration of creatinine in the blood contributes to age. After 50 years, the processes of extinction begin. The older the woman, the lower her creatinine.

Physiological causes can lead to an increase in the level of matter. An increase in the concentration of creatinine in the blood is due to an increase in muscle mass. The value of the indicator is increased in women who are constantly involved in sports, and also work in hard physical work. The results of the analyzes will also affect the consumption of a large amount of protein food. In this case, to bring the value of the indicator back to normal, it is enough to adjust the diet.

Blood creatinine

Creatinine is a participant in energy metabolism in the muscles of the body and other organs. Therefore, the content of non-protein compounds in the blood depends on muscle volume. Hence, in men, the amount of creatinine in blood serum is in greater quantity than in women - due to the volume of muscle mass.

Normally, the substance in the blood is almost always in a certain amount, which is determined by the relative stability of the muscle volume.

Causes of Increased Blood Creatinine

For some individuals, a slightly increased indicator is the normal level of creatinine in the blood. It is observed in the following categories of people:

  • professional athletes - or persons whose work is associated with heavy physical exertion,
  • observing a diet - the basis of the diet includes meat and high-protein food,
  • taking medications - tetracycline and cephalosporin antibacterial drugs.

The indicated reasons are physiological, do not manifest themselves clinically and do not require special correction.

A pathologically elevated creatinine level is usually accompanied by the appearance of symptoms such as pulling pain in the lower back, unmotivated weakness, fatigue, drowsiness, and impaired consciousness. This symptomatology can be associated both with an increase in the metabolite from the muscles, and with a violation of its excretion.

  • Acute and chronic renal failure. Glomerulonephritis, pyelonephritis, polycystic, toxic nephritis.
  • Severe heart failure. Pathology with a decrease in glomerular filtration resulting from impaired blood flow through the vessels of the kidneys.
  • Hyperthyroidism Thyroid hormones increase basic metabolism, including in skeletal muscle, which is accompanied by excessive formation of creatine.
  • Oncology. Some malignant tumors affect muscle tissue, causing its breakdown. The consequence is a significant increase in creatinine levels.
  • Injuries to muscle damage. Burns, prolonged squeezing syndrome.
  • Radiation sickness . Due to the destruction of myocytes under the influence of ionizing radiation.
  • Dehydration. A relative increase in creatinine due to a decrease in plasma volume.

Pathological causes

Pathological abnormalities can also lead to a change in the amount of creatinine in the blood of women after 50 years. They can lead to this:

  • dehydration,
  • heredity,
  • chronic kidney disease
  • muscle injury
  • endocrine diseases
  • low blood pressure.

The list is not exhaustive. To determine the exact cause, additional studies are prescribed.For this, a determination of clearance can be carried out - the degree and speed of kidney excretion of creatinine after its intravenous administration. In addition, a clinical analysis of urine is performed, which allows to identify a number of criteria indicating the course or absence of pathological processes. Depending on the underlying cause, additional studies may be prescribed. When there is enough data, a diagnosis is established and adequate treatment is prescribed.

Lower muscle protein

Reduced creatinine is much less common. Such a deviation develops in the following conditions.

  • Malnutrition. With an unbalanced diet with a small amount of meat and protein products, with starvation, in people who follow a vegetarian diet.
  • Pregnancy Due to the physiological increase in the volume of circulating plasma.
  • Muscular dystrophy. Both congenital and acquired, with a violation of the flow of creatinine from myocyte cells into the blood.

Symptoms indicating creatinine deviation from the norm

Pathologies of the kidneys are accompanied by a change in the color of urine (turbid urine, brown, "coffee", the color of meat slops, etc.). The patient has a sharp decrease in the amount of urine excreted per day. Among the typical symptoms are also distinguished: accumulation of fluid in the abdominal cavity (ascites), swelling of the face and limbs.

Urination causes pain, pains are felt. Often, pain affects the lower back and hypochondrium. A person feels weakness and fatigue, concentration of attention and appetite are falling. Concerned about sleep problems and jumps in blood pressure.

With infectious damage to the kidneys, febrile symptoms are noted.

If the above symptoms occur, you should undergo an examination, including determining the level of creatinine in the blood and urine.

Read on: Urine creatinine rates and causes of abnormalities

Table of creatinine norm by age in women:

Age yearsThe rate of creatinine, micromol / l
16-2051-81
20-5050-97
50-6055-88
Over 6060-89

In men, the average level is higher - from 74 to 110 μmol / L.

The indicator may fluctuate slightly under the influence of lifestyle - sports, diet, etc.

Creatinine increased

An increase in blood creatinine is accompanied by increased fatigue, weakness, shortness of breath, and dehydration. Depletion of all systems is observed. Malfunctions may occur in the rhythm of breathing. A woman suffers from depressive disorders. They can lead to this:

  • severe kidney damage
  • urolithiasis disease,
  • muscle injury
  • low blood pressure
  • chronic kidney disease,
  • violation of the water-salt balance,
  • severe dehydration,
  • intense bleeding that caused blood clotting,
  • pathological changes in the endocrine glands,
  • circulatory disturbance.

An abnormal ratio of nitrogen and creatinine can be a symptom of bleeding in the gastrointestinal tract and severe dehydration. If the analysis revealed a high level of creatinine clearance, this may indicate a pregnancy has begun.

How to determine renal pathology

In order to accurately determine the degree of kidney damage when elevated creatinine is detected, specialists calculate the glomerular filtration rate of urine in the kidneys and determine the level of urea. Unlike creatinine, its normal level is not dependent on gender and is 2.5-6.4 mmol / l for adults.

Creatinine clearance (ClCr - an indicator that characterizes renal filtration) is calculated by the formula:

  • in men - ClCr = ((140-age) * weight) / (72 * serum creatinine mg / dl),
  • in women, ClCr = ((((140-year-old) * weight) / (72 * serum creatinine mg / dl)) * 0.85.

Deviations from the norm: possible causes

Small physiological fluctuations in creatinine cause several factors.

To increase the performance lead:

  • sports, especially those types in which the result directly depends on the set of muscle mass (especially the use of special sports supplements),
  • physical labor is the same training
  • a diet with a lot of proteins, especially protein "carbohydrate-free" diets,
  • taking medications, for example, some anti-inflammatory drugs, antibiotics, etc.
  • in the first trimester of pregnancy, especially with severe toxicosis,
  • with diets that restrict the use of protein, for example, vegetarian,
  • with a sharp decrease in weight.

In these cases, deviations in creatinine are small, it is enough to eliminate or correct the cause, and everything will come to order.

If the deviations are significant (tens of micromoles) over time, then the reasons are more serious than the “imbalances” in the lifestyle, and you need to urgently consult a doctor, be examined and treated.

How to prepare for a blood test for creatinine?

Preparation before a blood test for creatinine consists of:

  • refusal to eat 12 hours before the collection of biomaterial, smoking - 1 hour,
  • limitations of physical and psychological stress,
  • by prior agreement with the attending physician, the administration of drugs is limited to the extent possible.

The sensitivity of the criterion to external and internal factors determines the fundamental importance of observing the rules of patient preparation.

The material for determining creatinine levels is venous blood.

Unreliable low results may result in:

  • improper taking of biomaterial, resulting in the destruction of red blood cells with the release of their contents. The biochemical composition of the blood is distorted. In this case, a repeat test is mandatory,
  • pregnancy, especially the first two trimesters. After conception, the amount of blood in a woman’s body doubles. This enhances the filtration process and the active removal of creatinine.

On the contrary, false positive data is facilitated by:

  • the percentage of muscle mass is above normal. Similar situations are especially characteristic for weightlifters,
  • diabetes mellitus in the patient’s history, against the background of which the concentration of simple sugars, acetone and urea increases,
  • extensive muscle damage
  • ascorbic acid drugs, barbiturates or aminoglycoside antibiotics.

Creatinine lowered

A decrease in creatinine levels often occurs as a result of physiological processes. Muscular dystrophy or aging are the causes of decreased muscle mass. All this leads to the fact that the concentration of the substance in the blood also decreases. A similar situation occurs if a person follows a low-protein diet or is a vegetarian. Pregnancy can also cause a decrease in the amount of the substance.

Chronic kidney disease may be suspected if creatinine clearance is low. Such changes can cause the development of malignant neoplasms, obstruction of the urinary tract, dehydration or heart failure. Violation of the ratio of nitrogen and creatinine can cause the following reasons:

  • severe injuries
  • insufficient amount of protein from food,
  • Parhon's Syndrome,
  • taking antibiotics
  • CNS diseases
  • lung diseases.

Losing weight can also cause a similar phenomenon. Identification of the root cause of a decrease in creatinine levels requires objective diagnosis.

Deviation correction

How to lower high creatinine in the blood? With slight deviations and the absence of pronounced symptoms of damage to the internal organs, it is possible to achieve a decrease in this indicator by normalizing the lifestyle.At home, this is possible by reducing physical activity to moderate, maintaining water balance (an adult needs to drink at least 30 ml / kg of water per day) and normalizing nutrition. The menu should contain no more than 200-250 g of protein per day, while it is worth abandoning fatty meats in favor of veal and chicken breast.

Reviews indicate that folk remedies will help if the kidneys are not affected. In order to correct the condition, you can use decoctions of diuretic herbs (nettle, sage, dandelion). You can take them only after consulting a doctor. Do not self-medicate, because if the glomerular filtration is disturbed, this can cause great harm to the body.

With a pathologically strong increase in plasma creatinine, the following measures are taken.

  • Detoxification. Intravenous infusion of crystalloid solutions (rheosorbylact) in combination with diuretics.
  • Treatment of renal failure. Blood purification during hemodialysis, peritoneal dialysis.
  • Diet Mandatory correction of nutrition with a decrease in the level of protein products and salt.

Raising abnormal blood creatinine levels is easier. To this end, doctors recommend the following measures.

  • Sport Moderate physical activity (at least 30 minutes every day).
  • Daily regime . Compliance with the duration of sleep and rest (sleep is important at least seven hours a day).
  • Nutrition . Normalization of the diet, the inclusion of meat, fish, dairy products.
  • Drinking mode. You need to drink at least eight glasses of water per day.
  • Vitamins Reception of vitamin-mineral complexes and protein preparations.

If the creatinine level deviates from normal values, you should not try to cope with it yourself. Even if the creatinine norm in the blood is slightly exceeded, this can indicate a serious pathology that requires a thorough examination and medical advice.

What is dangerous deviation from the norm

Creatinine (the norm in the blood is an indicator of the coordinated work of the body) should have a stable value in the biochemical analysis of blood and any deviations - up or down should be regarded as a pathological process in the body.

Increased serum creatinine:

  • acute pathological condition of the kidneys, in which the organ is not able to partially or completely remove urine,
  • long-term progressive decrease in kidney function in the form of insufficient blood filtration, removal of metabolic products and removal of excess fluid from the body,
  • with chronic pathologies in the myocardium and blood vessels,
  • impressive burns on the body,
  • after extensive surgery on the muscles of the body,
  • neoplasms, both benign and malignant,
  • pathological process in the thyroid gland or pituitary gland,
  • large fluid loss by the body,
  • nephrectomy
  • increased creatinine, as a result of taking medications,
  • a large amount of protein food in the diet.
Causes of abnormality of creatinine levels in the blood.

Decreased creatinine level:

  • long-term plant diet
  • weight loss with a decrease in muscle volume,
  • the first 30 weeks of pregnancy
  • systemic glucocorticoid therapy,
  • Stage 4 cancer,
  • violation of the production of vasopressin,
  • swelling
  • lupus nephritis,
  • psycho-emotional overload,
  • ischemic stroke,
  • the heat of passion,
  • stress
  • chronic inflammatory processes in the liver,
  • circulatory disorders in the hepatobiliary system,
  • nephropathy
  • pyelonephritis,
  • renal stone formation.

How to treat pathology?

Therapy with an increased level of creatinine depends on the cause that provoked the deviation from the norm. If the development of pathology led to a similar phenomenon, the fight against it is initially carried out. Patients may be prescribed medications that improve glomerular filtration.

It is imperative to limit sodium intake.Its amount should not exceed 2.4 g per day. To do this, you need to exclude from the daily menu:

The amount of meat is recommended to minimize.

If there is a decrease in creatinine in the blood, treatment will be aimed at combating the underlying pathology. If a lack of protein is detected, the patient is prescribed vitamin-mineral complexes. Additionally, you need to adjust the diet. It will be directly opposite to that which is appointed at increase of an indicator. In case of low creatinine, it is recommended to eat meat, fish, nuts and rice. Macaroni is also able to increase the number of indicators. It is recommended to increase physical activity. However, do not overexert the body.

Blood creatinine level is the norm in women

The norm of creatinine in the blood of women is directly related to age. The reference indicators for age categories are as follows:

  • from 14 to 18 years old - 44 - 88 μmol / l,
  • from 18 to 60 years old - 53 - 97 μmol / l,
  • from 50 years old - 53 - 106 micromol / l.

Thus, before reaching puberty, normal values ​​are lower by about 9 units, and after 50 years, the creatinine norm in women is on average higher by about 9 units.

In pregnant women, a significant decrease in the indicator relative to the norm is often observed. It is a very common situation when a woman expecting a baby, having learned the results of a blood test, is horrified that her creatinine is almost half the norm. In fact, this is a temporary phenomenon associated with the characteristics of physiology.

Preparation for creatinine test

In order for the results of the analysis to determine the content of creatinine to be the most reliable, you should:

  1. Exclude physical activity for two days.
  2. During the day, do not take alcohol, strong tea and coffee, eat less protein food.
  3. 8-10 hours before visiting the laboratory do not eat and drink only water without gas.
  4. Before taking blood, relax and sit for at least 10 minutes in a calm state.

Causes of a change in blood creatinine

High creatinine

An increase in creatinine, first of all, indicates pathological processes in the kidneys that have developed as a result of infection, a malignant tumor, insufficient blood flow or outflow. Other causes of increased creatinine are:

  • heart failure,
  • muscle injury
  • extensive burn wounds,
  • significant loss of blood, including with internal bleeding,
  • pathologies of the muscular system (myasthenia gravis, muscular dystrophy, etc.),
  • endocrine disorders (acromegaly, hyperthyroidism),
  • dehydration
  • radiation sickness.

In addition, creatinine levels are elevated in those patients who prefer meat food. Taking certain medications, including barbiturates, sulfonamides, thiazide diuretics, etc. can also lead to an increase in blood creatinine.

Attention! An increase in creatinine concentration is often observed in patients prone to obesity.

An increase in creatinine levels is accompanied by symptoms such as:

  • pain and a feeling of heaviness in the lumbar region,
  • labored breathing,
  • constant feeling of fatigue, loss of strength,
  • decreased appetite, nausea,
  • violation of urination up to a complete lack of urine,
  • high blood pressure
  • confusion,
  • cramps.

Low creatinine

Below normal creatinine levels can be caused by:

  • severe liver diseases, primarily cirrhosis,
  • a significant decrease in muscle mass due to long starvation or illness,
  • overhydration.

Long-term use of corticosteroids can also cause a decrease in creatinine levels.

As you have seen, the normal blood creatinine concentration is a sign of health. Figures that correspond to normal indicators are noted in those people whose organs and systems of the body function without significant problems.

Reviews: “This is a symptom of acute and chronic renal failure”

Increased creatinine is a symptom of acute and chronic renal failure, radiation sickness, hyperthyroidism. Creatinine levels increase after taking certain medications, with dehydration, after mechanical, surgical muscle damage. Increased creatinine is also possible in human blood, in whose diet meat food predominates.
Analysis of creatinine can show a decrease in blood creatinine, which occurs during fasting, a vegetarian diet, a decrease in muscle mass, in the I and II trimester of pregnancy, after taking corticosteroids.

Hello everybody! I just arrived from the RSCH, tested there, two weeks ago the creatinine was 2.6 (220), and today 3.0 ..................... horror. Before that, for several years, creatinine remained at the level of 1.5-1.7, this stability was calming. I already wrote on the forum (My story ...) that this is already the second presad (from dad), I thought that this kidney was for many, many years to come. I’m afraid to even think about the bad, but thoughts climb into my head. And my husband and son planned to travel by car in August on a long journey ... Lord. Really this will not happen. Tomorrow I’m going for a biopsy .. Maybe there’s someone who has their tests increased to high numbers, and then with the help of drugs they were reduced ?? Answer me. I’m afraid ... I don’t want to be strong again. I want to be a weak woman, wife, affectionate mother who is only concerned that her son goes to first grade ...

How does age affect creatinine levels?

Blood creatinine level depends not only on gender, but also on age. The older the person, the lower the level of the final non-protein compound in the body. The process is associated with an age-related decrease in muscle volume - when the fat layer increases due to slowed metabolic processes, and muscle decreases.

Therefore, lower creatinine levels, under normal health conditions, are the norm.

But even in people of a more mature age, the level of the final product of muscle work can be increased (to the norm of middle-aged people) - if an elderly person leads an active life, is engaged in physical education. In this case, a normal muscle volume will keep the level of non-protein compounds at the required level.

Diet with increased creatinine

With increased creatinine, diet is mandatory. First of all, you need to limit the amount of meat in the daily menu. However, do not completely exclude it from the diet. The amount of meat products should be reduced to 200g per week. Fatty varieties are best discarded altogether. They should be replaced:

In this case, the body should receive a daily protein intake. It is better to make up for it by eating eggs, nuts, dairy products and fish. The menu should be varied. It is recommended that you include a large number of fruits and vegetables. With increased creatinine, the following can have a beneficial effect:

  • Garnet,
  • porridge cooked on water
  • citrus,
  • Tomatoes
  • pumpkins.

Buckwheat porridge is of particular benefit. Useful and yeast-free bread with bran. Such a diet will reduce the production of creatinine and its entry into the blood.

You need to pay attention to the nutritional regime. Drink at least 1 liter of clean water daily. The action is recommended to be performed in the morning on an empty stomach or between meals. Drinking food is not recommended. Normalizing the amount of substance in the blood is also capable of reducing physical and mental stress.

When creatinine is elevated

The only reason that elevated blood creatinine is not considered a pathology is that it is knowingly voluntary. the use of various dietary supplements with a high concentration of the endogenous component for greater endurance and artificial muscle building.

What is often observed in professional athletes.

In other cases, increased titers of the endogenous component in the biochemical analysis of blood plasma provide grounds for a more complete examination of patients, since may testify:

  1. On the presence of pathological processes in the urinary system caused by a kidney injury, impaired renal blood supply, the development of urolithiasis or cancerous tumors.
  2. Increased indicators of the substance according to a hemorenal test are a characteristic symptom of high physical exertion, the body's reaction to a soft burn or muscle injury.
  3. A high level of creatinine in the analysis of azotemia may be a sign of renal failure, severe dehydration (dehydration) of the body, urinary tract obstruction, or hemorrhagic processes (bleeding) in any organ or system of the body (respiratory system, digestive tract, etc.).

Biochemical laboratory blood screening and a properly diagnosed doctor make it possible to choose a reasonable treatment strategy and prevent complications in time.

Adult Standards Table

Creatin in the blood (the norm is defined in mmol / l) in men and women - this is a different value due to the musculoskeletal structure.

Indicators of creatinine in men by age:

Age of menCreatinine Level in mmol / LMg%
from 18 years

up to 55 years old

from 0.085 mmol / l

up to 0.15 mmol / l

from 0.9615%

up to 1.6968%

from 55 years old

up to 75 years

from 0.07 mmol / l

up to 0.11 mmol / l

0,7918%

up to 1.2443%

from 75+from 0.06 mmol / l

up to 0.11 mmol / l

0,6787%

up to 1.2443%

Creatinine for women by age:

Women ageCreatinine Level in mmol / LMg%
from 18 years

up to 20 years

from 0.05 mmol / l

up to 0.10 mmol /

from 0,5655%

up to 1,13,11%

from 21 years

up to 50 years old

from 0.05 mmol / l

up to 0.11 mmol / l

from 0,5655%

up to 1.2443%

from 51 years old

under 60 years old

from 0.05 mmol / l

up to 1.06 mmol / l

from 0,5655%

up to 0.6787%

from 61 years old

up to 70 years

from 0.05 mmol / l

up to 0.98 mmol / l

from 0,5655%

up to 1.1085%

from 71+from 0.05 mmol / l

up to 0.80 mmol / l

from 0,5655%

up to 0.9049%

Normal values ​​for men

As a rule, men are characterized by a greater amount of muscle mass. This means that creatinine levels are higher than women.

Below is a table of creatinine norms in men by age. Up to 15 years of age, gender is not taken into account in the selection of reference values.

Man agePermissible values, micromol / l
Over 15 years old80 – 150
Men over 6071 – 115

The rate of creatinine in the blood in men after 60 years also increases slightly (against the background of an age-related decrease in the filtration capacity of the kidneys).

Preventative measures

As a preventative measure, experts recommend monitoring nutrition. Do not overload it with a lot of protein. However, it should not be completely abandoned. The menu should be as diverse as possible. A minimum of 1.5 liters of pure water is recommended per day. It is necessary to give the body a good rest. To do this, it is recommended to sleep 7-9 hours a day. Do not give too much exercise.

Experts advise not to ignore the passage of diagnostic examinations. All identified pathologies should be treated in a timely manner. This will reduce the chance of the disease developing into a chronic stage. Following the principles of proper nutrition and leading an active lifestyle without fanaticism will help minimize the likelihood of creatinine deviating from normal after 50 years.

Symptoms of increased creatinine: when you need to be tested

With kidney problems, a number of characteristic symptoms appear:

  • swelling
  • drawing pains in the lower back
  • violation of urine output (little or, conversely, too much, discoloration, etc.),
  • increased dryness of the skin,
  • high blood pressure
  • fatigue, muscle weakness,
  • dyspnea,
  • sleep disturbances
  • nausea, heaviness in the stomach,
  • confusion, blurred consciousness.

If you are concerned about these symptoms, consult your doctor immediately.

Creatinine should be tested periodically for those who have previously had kidney problems. If the disease decides to remind itself, it will help not to miss the moment and take measures in time.

A preventive examination is indicated for women during pregnancy and during menopause (a biochemical blood test is recommended to be done once a year).

Regularly check creatinine levels is recommended for patients with diabetes because of the risk of kidney failure.

Blood analysis. Creatinine - what is it?

One indicator of a blood test is creatinine. What is
is this substance? This is a molecular structure that is a product of muscle tissue metabolism.

It is produced from creatine, a molecule that plays an important role in the energy supply of muscle. In the process of human life, about 2% of muscle creatine is converted to creatinine and enters the bloodstream daily due to the creatine-phosphate reaction.

It should be noted that this substance is one of the few decay products that have a pronounced toxic effect on tissues, and must be removed. Creatinine levels are maintained by the kidneys, where blood is filtered and urine is formed.

During the day, the creatinine in the blood practically does not change, since the muscle mass of a person remains unchanged.

It is only natural that the blood creatinine norm in women and men will be different. Also, these indicators will depend on the age of the patient.

Table of standards for children

The creatinine index in childhood does not depend on gender. You should know that an increased rate of non-protein compounds in the blood can be with absolute health in a child - physiological indicators that are triggered by sports, increased weight, increased consumption of meat products, medications.

ChildhoodCreatinine Level in mmol / LMg%
up to 12 monthsfrom 0.017 mmol / l

up to 0.36 mmol / l

from 0.1531%

up to 0.3243%

from 1 year

under 12 years old

from 0.026 mmol / l

up to 0.063 mmol / l

from 0.2342%

up to 0.5675%

from 13 years old

under 18 years old

from 0.045 mmol / l

up to 0.089 mmol / l

from 0.4054%

up to 0.8017%

Causes of deviation of creatinine from the norm in a big way?

Deviation of the indicator from normal values ​​indicates a number of different diseases. Therefore, to clarify the reasons, additional biochemical studies are prescribed.

A high level of creatinine is observed in renal failure caused by a malfunction in protein metabolism, diabetes mellitus, or toxic damage to the kidneys. A similar condition also accompanies pathologies of the cardiovascular system, so it is advisable to consult a cardiologist.

Infections and oncological diseases of the urinary organs lead to a violation of glomerular filtration, which negatively affects the level of creatinine in the human body.

With glomerulonephritis, the destruction of the renal glomeruli occurs. Possible causes: manifestation of autoimmune diseases or infectious infection. The result - the creatinine content in humans rises.

Among kidney diseases, necrosis of the epithelial tissue of the renal tubules should be singled out separately. The condition is provoked by toxins or potent drugs.

Acromegaly and gigantism are another reason why the creatinine in the blood goes beyond normal values. The cause of the disease is excessive production of growth hormones by the pituitary gland of the brain. A change in the parameter under consideration is one of the many pathological processes that accompany acromegaly and gigantism.

With prolonged compression syndrome, large-scale destruction of muscle fibers and tissues occurs, which leads to the release of creatinine molecules into the systemic circulation.

Diagnostic Methods

Creatinine levels are measured in venous blood.

It is necessary to prepare for blood sampling: in 3 days, exclude physical activity, in 2 days - reduce the use of protein foods, stop taking medications (if this is not possible, warn the doctor).

Blood is given on an empty stomach, at least 9-10 hours after eating. You can drink some water without gas.

A standard creatinine test is a necessary but not sufficient method. For an accurate diagnosis, additional studies are performed:

  • Reberg’s test: the patient drinks half a liter of clean water, goes to the toilet, then donates blood and after another hour - urine,
  • creatinine clearance (from English clearence - cleansing): an indicator of the speed and quality of kidney function in venous blood and daily urine,
  • biochemical blood test: for creatine, urea, uric acid,
  • general urine analysis: important indicators - protein and white blood cells,
  • Comparative analysis for nitrogen and creatinine: the balance of these indicators helps determine where the source of the problem is - in the kidneys or in the heart,
  • cystatin C analysis: a new, more sensitive marker of kidney function.

It is important to remember: only a doctor can understand the results of studies, take into account all factors and features.

Blood creatinine in children

  1. Normal values ​​in newborns are usually in the range from
    55 to 90 μmol / L, but if the child has not yet reached the age of two weeks, then creatinine in his blood can rise to 110 μmol / L.
  2. During the first 12 months of life, creatinine in the blood of a child decreases every month by 5-10 units. Thus, the norm for a one-year-old baby will be 20–30 µmol / L.
  3. From a year to 14 years, an increase is again observed. This is due to an increase in muscle mass.

So, for a child aged 7 years, values ​​from 23 to 40 μmol / L are considered the norm, and after reaching 14 years, from 26 to 65 μmol / L.

In the puberty, differences in normal values ​​appear in boys and girls.

In sixteen-year-olds, indicators from 50 to 80 μmol / L are considered the norm for girls, and for boys - 60–95.

Non-Disease Causes

In addition to pathological reasons, creatinine levels are affected by:

  • severe overwork and high physical stress,
  • the predominance of meat dishes in the diet,
  • dehydration, leading to a thickening of the blood and a temporary increase in the rate,
  • drugs that have a toxic effect on the urinary organs.

To unequivocally exclude these reasons, one should extremely seriously approach the question of studying the rules of preparation for research. Particular attention is paid to limiting physical activity. On the eve of blood donation, by definition of biochemical parameters, including creatinine, sports should be excluded. Before a visit to the laboratory, morning jogging and exercise are also canceled.

Raising creatinine: what to do

Elevated creatinine levels are a symptom, and you must fight the cause.

If the problem is excessive loads or poor nutrition, adjust your lifestyle.

Reduce physical activity, revise the diet - eat less animal protein, replace fatty meats with veal or rabbit. Include more vegetables and fruits in the menu, cereals, especially buckwheat, are very useful.

Follow the drinking regimen - at least 1.5 liters per day, but only water, not sweet soda, strong tea or coffee.

Why is blood creatinine reduced?

Blood creatinine level decreases if a person goes without food for a long time, and his muscle mass has atrophied. In addition, the violation of water-salt metabolism leads to an increase and accumulation of free fluid in the body. Which ultimately contributes to water poisoning and a decrease in all biochemical parameters.

If a person prefers a vegetarian diet and does not eat enough meat, then naturally a decrease in muscle mass occurs. And that means the content of the indicator in his body.

Also, creatinine levels decrease during pregnancy, treatment with corticosteroids and with myodystrophies.

Main article: Causes of lower creatinine in women, men, children

Men Creatinine

In average men, the norm of blood creatinine is considered to be from 70 to 115 μmol / l. However, some factors need to be considered when making a blood test.

Decryption, in which creatinine exceeds normal values, may be in men who are constantly experiencing significant physical exertion.

So, this can be observed, for example, in athletes or people in whose diet there is an excessive amount of meat products. For older men, a decrease in indicators to 65–95 μmol / l is characteristic.

Why is increased creatinine dangerous?

It should be emphasized that a single increase in the indicator does not have sufficient diagnostic value. Since it is sensitive to many factors, including nutrition and physical activity.

The danger is a combined deviation from the norm of various biochemical parameters. Particular attention is paid to the content of urea and uric acid in the studied biomaterial (blood, single or daily urine).

The creatinine molecule is the final product that cannot be decomposed by the human body. This means that its accumulation leads to a gradual intoxication of various human systems and organs.

Critical situations, when the value of the indicator goes off scale, the patient undergoes hemodialysis for blood purification.

Ethnoscience

Tested folk recipes - decoctions with diuretic properties will help to remove creatinine from the body:

  • rosehip broth. Fresh or dried berries are brewed, insisted in a thermos and drunk like tea,
  • lingonberry. Lingonberry berries or leaves are brewed with boiling water, insisted and taken three times a day,
  • Garnet. Pour dry crusts with boiling water and drink during the day,
  • medicinal dandelion. Dandelion is a universal remedy; flowers, leaves, and roots are used. It is brewed as tea, fresh or dried herbs are added to dishes.

Be careful, do not get carried away: the diuretic effect of the good old folk remedies is very strong. To "cranberry water" you, as Onegin, "did no harm," consult a doctor.

Symptoms of Abnormality

The rate of creatinine in the blood may deviate and always be accompanied by certain symptoms.

Manifestations of increased creatinine:

  • rapid and labored breathing,
  • fatigue,
  • increase or decrease in blood pressure,
  • rambling thinking
  • inability to think and think clearly
  • great desire to drink,
  • pathological accumulation of fluid in tissues and organs,
  • vomiting reflex,
  • heaviness in the stomach,
  • violation of water and lipid metabolism in the form of dry skin,
  • soreness and muscle weakness,
  • increased or vice versa reduced separation of urine during the day,
  • pathological changes from the general analysis of urine - the appearance of protein, leukocytopenia and erythrocytopenia,
  • painful and painful sensations in the lumbar spine,
  • hypertension

Symptoms of decreased serum creatinine:

  • violation of the absorption of nutrients,
  • dyspeptic disorders
  • digestive disorders of unknown etiology,
  • malfunction of the hepatobiliary system,
  • a feeling of weakness throughout the body,
  • anorexia,
  • decreased motor and physical activity,
  • pain in the area of ​​the heart muscle,
  • asthenic condition
  • psycho-emotional instability.

How to determine creatinine level?

In the event that the patient does not have the opportunity to visit the laboratory in the morning, the procedure is carried out after at least 6 hours of fasting, while fats should be excluded in the morning meal. It should be borne in mind that juices, coffee, tea (especially with sugar) are also food, so it is better to replace them with water.

Only under these conditions can a reliable blood test be obtained.

How to lower blood creatinine?

Separate treatment to reduce the rate does not exist. Its reduction can be achieved exclusively by treating the underlying disease, which provoked an increase. For this, a drug therapy is selected for a person and a rational diet is drawn up.

A diet with increased creatinine is extremely important, it helps to improve the biochemical composition of the blood and facilitate the treatment of the underlying disease. It is recommended that the patient limit or completely abandon the use of salt and salty foods.

How to control the amount of salt used? For this, the patient is forbidden to salt all cooked dishes. The permitted amount of table salt is given to the person in his arms, and he can independently add the dishes. In this case, not exceeding the permitted volume of salt.

The amount of animal protein consumed is also reduced. If the diet contains 70 grams of protein, then only a third of them can be of animal origin. In severe kidney damage, the amount of animal protein is reduced to 10-20 grams per day.

As an alternative, it is recommended to use dairy products, eggs and low-fat varieties of lean fish. Important: the duration of the low-protein diet is determined by the attending physician based on the patient's condition.

According to the indications, the patient can be transferred to a protein-free diet.

After repeated analyzes, further treatment tactics are determined. A decrease in creatinine indicates the possibility of increasing the amount of animal protein consumed.

The absence of positive dynamics in the return of the indicator to normal indicates the inefficiency of the selected treatment methods and the need for their correction. In parallel with this patient, holding fasting days is recommended.

What does elevated blood creatinine show?

Receiving the results of the analysis, an uninitiated person often does not know what creatinine in the blood means and what deviations in the work of internal organs he can show. As a specialist, an increase in creatinine can signal the following conditions:

  • impaired renal function - acute or chronic renal failure,
  • significant damage to muscle tissue, which can be caused by trauma or certain diseases (gangrene, tissue necrosis),
  • dehydration of the body (in this case, the concentration of all substances begins to increase),
  • intestinal obstruction or obstruction of the urinary canals,
  • extensive burns
  • some endocrine diseases (hyperthyroidism, acromegaly),
  • the presence of profuse internal bleeding with peptic ulcer of the stomach or intestines, as well as with various tumor diseases,
  • excessive consumption of fish and meat dishes - they have a very high concentration of toxic substances, which, getting into the blood, cause an increase in creatinine.

An increase in creatinine levels also occurs with constant heavy physical labor or stress for which the body is not prepared. Diets, starvation, or the use of certain drugs can also lead to an increase in creatinine.

Drug therapy

If the examination revealed that elevated creatinine is a symptom of serious diseases, then medicines are needed that will normalize the processes of protein metabolism and help to remove toxic decay products.

There are several such drugs (Ketosteril, Trinefron, Lespefril, etc.), each of them has peculiarities in prescribing and course treatment - do not try to figure it out without a specialist.

The kidneys are a very sensitive organ, with untimely or improper treatment, the risk of serious consequences is high, when only hemodialysis or donor kidney transplantation will help.

Indications for appointment analysis

The main indication for a blood creatinine test is to determine how well the urinary system works.

You should know that there are pathologies, the development of which can be determined by the level of non-protein compounds in the blood:

  • edematous syndrome
  • violation of the allocation of urine - a decrease or complete cessation,
  • pain and heaviness in the lumbar spine of a non-degenerative nature,
  • heaviness in breathing
  • fatigue,
  • pathological changes in the myocardium,
  • autoimmune pathological processes in the body associated with visceral lesions,
  • type 1 and type 2 diabetes
  • clinical and biochemical analyzes before surgery,
  • gestation period,
  • systemic glucocorticoid therapy,
  • taking antibacterial agents,
  • in athletes, to monitor the proper functioning of the kidneys during the intake of protein and creatine supplements,
  • intermittent increase in pressure,
  • hypertensive crises with pathological atherosclerotic vascular damage,
  • painful spasm of the muscles of the body,
  • postoperative period on large surfaces of the body.

To summarize

Increased creatinine is a danger signal that the body gives. It manifests itself in diabetes mellitus, endocrine disorders, and kidney pathologies.

The best prevention of these diseases is to lead a normal lifestyle without rushing to extremes:

  • avoid too much physical exertion, rest regularly and fully,
  • eat right: eat less salt and sugar, spicy and fat, do not get involved in diets,
  • to refuse from bad habits.

Treat yourself and your health responsibly: do not start the problem, do not self-medicate, for any disturbing symptoms, consult a doctor.

Symptoms of High Creatinine

As a rule, an increase in creatinine in the blood leads to the appearance in humans of a classic picture of kidney damage. These include:

  • lower back and lower back pain
  • violation of diuresis (urine output) - this can be either a complete absence of urine (anuria), or the release of 2 liters or more (polyuria),
  • hypertension syndrome - increased blood pressure,
  • swelling
  • in the analysis of urine, protein and red blood cells are detected.

If the patient's creatinine values ​​increase, and the clearance (this is an indicator of the ability of the kidneys to filter a certain amount of blood in one minute) decreases, then there is increasing fatigue, nausea, loss of appetite, anemia, shortness of breath. In severe cases, there may be confusion or loss of consciousness, convulsions.

Important findings

To summarize, it is important to emphasize the following points:

  • creatinine is a sensitive indicator that responds to changes in the kidneys and damage to muscle tissue. That allows you to attribute it to indicators of the state of the kidneys,
  • creatinine testing alone is not enough to establish a definitive diagnosis,
  • when deciphering the results, one should take into account gender, age, stage of pregnancy of the examined patients,
  • a single deviation from the norm is not enough to confirm the fact of kidney pathologies. It’s important to get ready and repeat the study,
  • methods to reduce creatinine are aimed at eliminating the underlying pathology that caused its increase.

Read on: How to lower blood creatinine - treatment, diet and more

Analysis preparation

Before taking a blood creatinine test, certain rules must be followed, so that there are no distortions as a result of the analysis:

  • it is necessary to exclude any types of alcohol a day before the test,
  • you should abandon the large intake of protein foods (if you have a habit of eating one meat), so that the analysis does not show an artificial increase in creatinine in the blood,
  • exclude sharp seasonings and pickled food from the diet per day,
  • do not engage in heavy physical exertion and sports for 2 days (before donating blood),
  • before taking the test, you should not eat food for 12 hours,
  • exclude psycho-emotional stress,
  • before donating blood, you can’t drink anything except a glass of water,
  • it is necessary to warn the medical worker about taking systemic drugs - antibacterial anti-tuberculosis therapy, glucocorticoid drugs (if any),
  • if possible (with the permission of the attending physician) - stop using all medications,
  • Before entering the handling room you should relax.

Increased creatinine - what to do?

If blood biochemistry revealed an increased content of creatinine, first of all, do not take any independent actions. In this case, consultation with a specialist and a thorough and comprehensive examination are mandatory. Only then can a comprehensive list of recommendations for reducing creatinine be developed.

If the deviation from the norm is insignificant and there are no alarming symptoms, the actions, as a rule, come down to adjusting the diet and lifestyle. In the event that the creatinine level is significantly higher than normal, medication is inevitable.

Usually, in this case, medicinal substances are prescribed that normalize the process of protein breakdown.

How to lower creatinine

In order to normalize the level of creatinine in the blood, it is necessary
pay attention to your diet. First of all, you need to limit the consumption of meat. At the same time, it is not at all necessary to completely exclude it from your diet - it is enough to reduce its amount to 200 grams per week.

Fatty varieties should be completely eliminated and replaced with white chicken, veal, and rabbit. The protein norm, which should be present in the daily diet, in this case, it is better to make up for at the expense of eggs, dairy products, fish, nuts.

It is recommended to diversify your menu by including a large number of fruits and vegetables. Especially useful in this situation will be pumpkin, tomatoes, pomegranates, citrus fruits, as well as cereals cooked on water (in this regard, buckwheat is especially worth noting) and unleavened bread with bran.

Such a diet helps to reduce the production and, accordingly, the flow of creatinine into the blood.

It is very important to pay attention to the drinking regimen - you need to drink at least a liter of clean water per day. This should be done in the morning, on an empty stomach or between meals, but not during meals. In addition, moderate physical activity will help normalize creatinine.

As you can see, the norm of creatinine in the blood of women and men is an important indicator of the work of all organs and systems of the body. These indicators are of particular importance in the diagnosis of kidney and liver function. In order to avoid possible serious health problems, it is worth paying attention even to minor deviations from the norm.

Julia Martynovich (Peshkova)

Graduated, in 2014 she graduated with honors from the Federal State Budget Educational Institution of Higher Education at the Orenburg State University with a degree in microbiology. Graduate of postgraduate studies FSBEI HE Orenburg State Agrarian University.

In 2015 The Institute of Cellular and Intracellular Symbiosis of the Ural Branch of the Russian Academy of Sciences underwent further training under the additional professional program "Bacteriology".

Laureate of the All-Russian competition for the best scientific work in the nomination "Biological Sciences" of 2017.

Blood creatinine is elevated - causes, rate indicators in women, men and children

A standard biochemical blood test can detect changes in serum or plasma creatinine concentrations. These data are used to diagnose kidney function if necessary.Sometimes indicators go beyond the norm, but why does blood creatinine increase? The reasons for this deviation are discussed below.

Creatinine Normalization Methods

When determining creatinine levels, the general practitioner first aims to see the result of the analysis. As a rule, he is interested in whether the level of non-protein substance in the blood serum is elevated.

To normalize a lowered level of creatinine, you should usually adjust your physical and emotional stress, abandon bad habits in the form of alcohol, tobacco, physical inactivity - the enemy of lowered creatinine. To lower the level of creatinine in the blood, you should know the reason.

Based on the examination, the therapist, urologist, infectious disease specialist (it all depends on the pathological process) will offer therapy:

  • drug therapy (if there is a disease),
  • alternative methods of treatment (traditional medicine),
  • diet food.

How to increase creatinine levels with medication

In order to increase the level of creatinine in the blood, you should know the reason. The lack of a non-protein compound, as a rule, does not bother doctors, and this problem should be treated first of all by observing a diet - with a high content of animal proteins, an active lifestyle.

But there are pathological conditions in which drugs should be taken that will help the general metabolism in the body.

The drug methionine tablets:

  • the composition of the product includes alipophic sulfur-containing amino acid,
  • the drug stimulates the liver, normalizes lipid metabolism, stimulates the production of vitamin B4, the hormone adrenaline and non-protein substance creatinine,
  • should be taken with liver lesions of various etiologies, with type 1 and type 2 diabetes,
  • to increase the level of creatinine in the blood should be taken 2 tablets 4 times a day. The duration of therapy is from 15 to 30 days with a break of 2 weeks, a second course should be done.

Ketosteril tablets:

  • a combined amino acid-polypeptide preparation that contains - hydroxy amino acid, l-tryptophan, heterocyclic amino acid, alpha amino acid,
  • the drug helps the body in replenishing amino acids that are lacking for vital functions, promotes the production of creatinine, improves metabolic processes,
  • the drug must be used with insufficient protein metabolism,
  • you need to drink 4 tablets 3 times a day. The duration of therapy is determined by the general practitioner.

Dry preparation Nutrizone for oral use:

  • the preparation contains proteins - 6 g, fats - 5.8 g, carbohydrates - 18.3 g,
  • the drug is a highly nutritious mixture with a lot of protein, vitamins, fats and carbohydrates,
  • the drug should be taken with exhaustion, lack of creatinine in the blood,
  • Fine powder should be added to food or should be diluted with water and drink. The dose of the drug is determined by the physician or nutritionist in accordance with the patient's needs.

Drug Modulon IBD:

  • the composition of the drug for oral administration includes a large number of proteins, omega-3 and omega-6 polyunsaturated fatty acid, powdery corn carbohydrate syrup, cane sugar,
  • highly nutritious combination protein mixture to eliminate protein deficiency, low serum creatinine, anorexia,
  • the drug should be added to food or drinks. It should be taken strictly as prescribed by the attending physician and in accordance with the prescribed dosages.

The drug for intravenous administration Nutriflex Lipid:

  • the medicine consists of a liquid solution of grape sugar, a regenerating emulsion of lipids, amino acid composition, ionic salt solution,
  • the drug provides energy to all cells and tissues of the body,
  • the drug should be administered intravenously, continuously, in dosages and amounts prescribed by a resuscitator or other specialist and only in a hospital setting.

Drug Creatinine Lowering

Blood creatinine (the norm of a non-protein compound is increased in certain diseases) can have not only a low level (a rather rare phenomenon), but also high, which should be taken very seriously.

First of all, you need to change your usual lifestyle:

  • Be sure to establish the use of clean water - not tea and coffee,
  • reduce and sometimes eliminate (for some time) physical activity,
  • eliminate psycho-emotional provocateurs,
  • you should abandon bad habits - alcoholic beverages, in all forms and tobacco.

Normalization of creatinine indicators folk remedies

Alternative medicine is widely used to normalize the level of non-protein compounds in the blood. To do this, you need to use herbal teas and infusions from plants, prepared at home.

  1. Ceylon Cinnamon Tea Dried tree bark should be brewed as tea and drunk 3 times a day before meals. Helps improve diuresis.
  2. Medicinal dandelion. The plant must be used for brewing tea, as well as added to dishes in raw and dried form. Helps the urinary system, contributes to the overall strengthening of the body, is a tonic.
  3. Drink from berries of a wild rose. The berries should be steamed in a thermos. Infusion taken in a weak form as a drink, you can instead of water. Enhances diuresis, promotes the withdrawal of small crystals from the kidneys, thereby improving blood circulation in the urinary system and lowering creatinine levels,
  4. Tea from berries and leaves of lingonberry garden. A small amount of the product must be poured into a glass, pour boiling water. Insist. Use instead of tea 3 times a day. Helps urine removal.
  5. A decoction of sage. Helps improve kidney function, as well as remove excess creatinine. It should brew 1 tsp. medicinal herbs with boiling water, wait until it is infused (15-20 minutes) and drink before meals.

Increased blood creatinine for physiological reasons

There are two factors that can explain why creatinine in the blood is elevated - pathological and physiological.

The first is caused by diseases that affect the functioning of the kidneys, the second is a natural reaction of the body to external and internal changes that are not dangerous to health.

All these factors during the examination must be announced to the doctor. Blood creatinine increased - physiological reasons:

  1. Age. In older people, the level of this substance may fluctuate slightly, which is the norm. In adolescence in children (time of active growth), an increase in the amount of the element in question is observed. After that, the level should normalize.
  2. Floor. Compared with men, in women, the indicator should be lower (subject to the same age), which is explained by a smaller volume of muscle mass.
  3. Pregnancy, hormonal background (in women in particular). These two factors can increase protein metabolism, which will lead to the growth of the substance.
  4. Physical exercise. For athletes, people who are engaged in active physical labor at work, the norm of the substance should be higher.
  5. Muscle mass, their volume. This factor must be taken into account in the biochemical analysis of the serum of athletes who are involved in weightlifting, bodybuilding. The more muscle, the higher the rate, which is not considered a symptom of impaired renal function.
  6. Nutrition. Many athletes follow a protein diet to stimulate muscle growth. A large amount of protein leads to the fact that creatinine in the blood is increased.The same effect is observed with prolonged starvation, which also provokes the destruction of muscle fibers to generate energy.
  7. Nutritional supplements that contain the amino acid creatine also cause the element to be elevated in plasma.

High creatinine in the blood for pathological reasons

The second group of reasons why creatinine rises refers to pathological abnormalities. This phenomenon is called hypercreatininemia. It can be an additional symptom of other diseases and be the main criterion for diagnosis. The degree of growth of the substance may indicate the causes of the development of a pathological condition. Two stages of hypercreatininemia can be distinguished.

Moderate, insignificant - reasons:

  • kidney pathology, organ failure 1, 2 degrees,
  • the cause is inflammatory, toxic or cirrhotic liver damage,
  • an increased rate is observed due to massive necrosis of tissues, gangrene of internal organs, limbs,
  • growth is due to extensive burns, damage to bones, muscle tissue,
  • thyrotoxicosis - hyperthyroidism,
  • an increased rate provokes diabetic nephropathy, which was caused by diabetes,
  • myasthenia gravis
  • adrenal hyperfunction,
  • the cause of increased importance may be toxic effects on the body from harmful substances, severe pathologies, for example, intestinal obstruction, infection, peritonitis,
  • drugs that have a nephrotoxic effect are able to affect the body, which provokes an elevated level of the element,
  • the cause may be toxicosis, which complicates the course of pregnancy,
  • excess fluid loss or its insufficient intake in the body leads to an increased value,
  • massive damage to connective tissue due to an autoimmune disease (lupus erythematosus, rheumatoid arthritis),
  • decompensated heart failure, which has a pronounced stagnation in a large circle of blood circulation, causes an increased content of the element.

Severe (dangerous) hypercreatininemia:

  • 3.4 degree renal failure due to kidney disease provides an increased level,
  • extensive inflammation of the muscles,
  • the cause of the increased value of the substance is the destruction of muscles in large quantities during muscular dystrophy,
  • increased content can be observed with prolonged compression of large muscle masses,
  • leptospirosis, other severe infections.

What causes a decrease in blood creatinine in women?

For example, for pregnant women, a decrease in blood creatinine of about 40% is considered normal, due to the increase in blood volume and the volume of filtration of the kidneys. Most often, this is noticeable in the second or third trimester of pregnancy.

Also, reduced creatinine may indicate that the woman is starving, sitting on a vegetarian diet, undergoing hormone therapy, for which corticosteroids are used.

What causes a rise in blood creatinine in women?

The content in the blood may increase due to the fact that the kidneys are disturbed.

To accurately diagnose renal failure, you need to not only determine the level of creatinine in the blood, but also use the Roberg test for this purpose.

To do this, creatinine is injected into the body, then it is analyzed at what speed it is excreted through the kidneys, changes in the concentration of creatinine in the blood and urine are monitored.

Renal failure can have an acute and chronic head start, because of this, urea and creatinine products gradually accumulate in the blood, because of this the exchange of water, electrolytes - calcium, chlorine, sodium ions, etc. is disrupted.

Kidney problems occur due to acute inflammation, jade, infection in the genitourinary system, with the negative influence of harmful substances, if patency in the urinary system is impaired.

Renal failure develops rapidly if a woman loses a lot of blood after an injury and burn.

The chronic form of the course of the disease is dangerous because the kidneys begin to completely lose their function, while over time the cells die, the structural and functional structures of the kidney - nephrons die.

Depending on how fast the blood is cleared of creatinine, you can say whether a woman has kidney failure or not. This method is sensitive and helps to identify the first signs of kidney pathology than a blood test to determine the level.
When creatinine level rises, this may indicate that the woman has a weight problem, she is obese.

Deviation from the norm upward can occur due to mechanical injuries in muscle tissue, with dehydration, with increased formation of hormones in the thyroid gland, with diabetes mellitus, a sharp violation of the functionality of the liver, inflammatory lung diseases.

Problems with the endocrine system are a common cause of increased creatine, with acromegaly and gigantism, the hypothalamus is disrupted, the pituitary gland can be affected, and more somatotropic hormone is produced, and muscle mass is increased due to this. Gigantism begins to develop from childhood, acromegaly most often appears in adulthood, when the skeletal system is fully formed.

In addition to pathological processes in a woman’s body, creatinine can increase due to physiological characteristics of life. Often the level rises after strong physical exertion, rises among women athletes and physically undeveloped women, of course, in the last group the indicators are higher.

Women who are on a meat diet also have an elevated level due to the fact that exogenous creatinine comes with food.

To bring the creatinine in the blood of a woman back to normal, it is very important to know the reason because of which the level rises or falls, it is necessary to eliminate it.

Female creatinine test requirements

1. Research should be done in the morning.

2. Blood is taken from the ulnar vein.

3. Material is taken only 8 hours after eating, so it is so important to take an analysis on an empty stomach.

4. With the help of informative results, a specialist will be able to give you the correct diagnosis and decide on further treatment.

5. If a woman has mechanical damage in the body or if she underwent surgery, an analysis of creatinine makes it possible to find out about muscle tissue and its condition.

Women definitely need to conduct a timely analysis on creatinini, in this way they can at an early stage learn about kidney diseases - clogging of the urinary tract, renal failure.

It should also be borne in mind that when taking certain drugs, kidney function may also be impaired, because of this, creatinine levels increase. Thyroid pathology also affects - hyperthyroidism, abnormalities in women can occur with dehydration.

But you can’t talk about the problem after one analysis, in order to clarify the diagnosis, you need to undergo a full-fledged comprehensive examination in order to find out the true reasons why creatinine is abnormal. The examination should be mandatory, because if changes occur - increase or decrease, this already speaks of a specific disease.

A woman’s body is a complex system; for its functioning, full-fledged work of all organs is needed.

The kidneys are one of the important organs, they are a filter, they remove substances that have broken up, help cleanse the blood, remove water and other harmful substances in the urine, and, of course, salt, which negatively affects the body. Creatinine is an important indicator that characterizes the functioning of the kidneys.

So, it is very important to control the creatinine norm for a woman, because deviations indicate serious diseases that require immediate treatment. It is especially important to monitor creatinine levels for pregnant women.

Why is it important to check your creatinine level in the blood?

The amount of creatinine in the blood is an indicator of the state of the muscles and the functioning of the urinary system. Its changes can be caused by both physiological and pathological reasons.

Basically, the level of this substance in the blood is used to diagnose dehydration, kidney and cardiovascular diseases, malignant neoplasms of muscle tissue, hyperthyroidism and radiation sickness.

Changing the biochemical parameters of blood is one of the earliest signs of these diseases, and allows you to identify pathology in the early stages and prescribe the most effective treatment.

The normal creatinine content changes with age and depends on the amount of muscle mass. In childhood, the norm in boys and girls is the same, differences between teenagers begin to appear, and in adult men the creatinine content is much higher than in women. With age, these differences smooth out, but not completely.

Table - the norm of creatinine by age (μmol / l):

Up to 1 month1 month - 1 year1 to 12 years12 - 17 years old17 - 60 years oldOver 60
M27 — 8818 — 3527 — 6244 — 8874 — 11072 — 127
F27 — 8818 — 3527 — 6240 — 7858 — 9653 — 106

Norms of creatinine in men are shown in the table for comparison. In women, starting in adolescence, a tendency toward a decrease in the amount of this substance in the blood is clearly visible compared with men. This is due to the fact that muscle mass in women grows much slower and generally less than in men.

Human plasma levels of creatinine

This metabolite enters the bloodstream almost constantly. Its concentration is different. It depends on gender, age, lifestyle, characteristics of labor activity, human physique. There is a conditional maximum and minimum of its content in the blood. According to these indicators, the state of internal organs (especially the kidneys) is determined.

The level of this metabolite gradually increases throughout life, but there are no sharp fluctuations in its concentration (unless, of course, a person has serious health problems). When old age comes, this growth accelerates a little.

Its concentration depends on:

  • what is a person’s kidney condition,
  • how developed is his muscle mass,
  • what foods he eats.

The norm of creatinine in female blood plasma

Women have less of it than men. The reasons for this are:

  • less (than men) muscle mass,
  • lower muscle activity
  • slower metabolic processes,
  • a diet with less exogenous creatinine,
  • the presence of estrogen (female sex hormones).

The rate of this metabolite depends on many factors. Age is the main one.

What is the increased concentration of creatinine

Hypercreatinemia - the so-called concentration of this metabolite, which exceeds the permissible norms. It does not lead to any serious health problems, does not have a strong detrimental effect on the body.

Since creatinine is low toxic, it becomes harmful only with very sharp fluctuations in its concentration. Such an acute form of hypercreatinemia is a sign of a variety of diseases. Often, the presence of a disorder indicates kidney disease.

Hypercreatinemia may be accompanied by the following symptoms:

  • muscle aches
  • chronic fatigue, feeling overwhelmed,
  • swelling
  • muscle weakness
  • a sharp fluctuation in the amount of daily urine,
  • changes in the content of blood cells, as well as protein in the urine.

Factors that cause hypercreatinemia are conditionally divided into external and internal. External factors - this is human activity, the impact on the environment. Internal ones are determined by physiological processes, the functional state of the body.

External factors include:

  • specific diets high in protein,
  • starvation,
  • increased physical activity, gymnastics, fitness, swimming, jogging,
  • a large amount of fluid drunk (3 or more liters per day),
  • artificial muscle building with steroid and steroid-like medications,
  • acute muscular dystrophy,
  • mechanical damage to muscles, burns,
  • crash (prolonged crushing syndrome),
  • gangrene of the hands or feet, which are accompanied by a severe form of arterial occlusion,
  • vomiting, diarrhea, which lead to dehydration.

A woman's creatinine level rises when she is expecting a baby, breastfeeding.

The internal factors, due to which the level of this metabolite is growing, include:

  • impaired renal function, because of which they normally do not remove creatinine from the body, various types of renal failure,
  • disorders of the ureter system,
  • water balance disorders, swelling,
  • redistribution of blood,
  • intoxication and inflammatory processes in the liver, which are accompanied by its dysfunction,
  • diseases of the endocrine system, which plays a key role in metabolic processes,
  • severe heart failure
  • pregnancy, which is accompanied by toxicosis,
  • excess activity of the adrenal glands (hypercorticism),
  • pathological weakness of striated muscles (myasthenia gravis),
  • leptospirosis.

Sometimes high creatinine levels are caused by changes in blood plasma volume. The reasons for this are blood loss, dehydration, redistribution of blood.

Diabetes mellitus, rheumatoid arthritis, and some other chronic diseases also cause an increase in the level of this metabolite in human blood plasma.

What causes low creatinine

Its lack of plasma is called hypocreatinemia. This is an infrequent phenomenon, in itself it does not mean the presence of a specific disease. Hypocreatinemia can be caused by serious problems with the metabolism of muscle tissue and protein. It is not connected with a condition of kidneys in any way.

The main reasons for the low concentration of this metabolite are:

  • rigid diets that cause severe depletion of the body,
  • cachexia caused by chronic diseases or starvation,
  • amyotrophy,
  • glucocorticoids, some other medications,
  • first trimester of pregnancy.

Ways to normalize creatinine levels

To reduce its concentration, do the following:

  • avoid stress
  • minimize physical activity,
  • drink enough water (at least 1.5 liters every day),
  • eat less protein food (especially meat, fish),
  • fewer foods rich in sodium (spicy, fried, pasta, milk, rice),
  • get enough sleep regularly.

There are many popular ways to lower creatinine. Herbal tea is one of them. Simple green tea is fine. It helps the kidneys, serves as a good diuretic.

Good lowers creatine nettle tea. He is rich in histamines. They help the kidneys better filter urine, remove more creatinine from the body.

Sage tea will also lower the level of this metabolite, as it contains useful magnesium for the kidneys.

Fluctuations in creatinine levels are not a good sign, but there’s no point in panicking. Just go to the doctor. If he determines that everything is good with the kidneys and other organs, then normalizing creatinine is a simple matter.All that is needed is to lead a healthy, active lifestyle, not to overwork and regularly rest.

When sent for blood creatinine analysis

Blood creatinine is usually studied simultaneously with total protein, residual nitrogen, and urea. Analyzes are taken in the morning on an empty stomach only after a quiet sleep, and not physical activity in the night shift. If the work is related to shift, you need to pass the analysis on another day, because the data obtained will be unreliable.

The rate of creatinine directly depends on the level of development and accumulation of muscle mass. The indicator is measured in the amount of dissolved micromoles in a liter of blood (µmol / l). Standards change throughout life. In the blood of healthy men, creatinine levels are always higher than in women.

Population groupsNorm in μmol / L
Children: during the neonatal period up to a year from a year to 10 years

from 10 to 18 years

27 – 88 18 – 35 27 – 62

Men: up to 60 years old
over 60 years old
80 – 115
71 — 115
Women: up to 60 years old
over 60 years old
53 – 97
53 – 106

The table shows the norms that doctors use to evaluate the level of creatinine in the blood. Deviations from these figures do not always indicate pathology.

Why does a healthy creatinine increase

The reasons for the increased creatinine should first be sought in human physiology. Now many people are involved in power sports. This is especially true for bodybuilding.

Athletes reinforce this process by taking anabolic hormonal drugs. Muscle building requires a significant amount of protein in the diet.

Accordingly, a blood test in such cases shows an increase in decay products.

Such muscles require sacrifice.

Girls to create a slim figure use advertised diets with a sharp restriction of fats and carbohydrates by increasing the proportion of protein products and vitamins.

Even more cruel - a hungry diet - causes increased energy extraction from protein, and not from carbohydrates, as usually happens. At the same time, the metabolic balance is disturbed: a low glucose level is observed in the blood, but the residual nitrogen of creatinine and urea is increased.

The reason for a significant increase in creatinine is any destructive processes in muscle tissue:

  • trauma, especially associated with prolonged compression of the tissues,
  • surgical intervention
  • extensive burns
  • decaying tumor
  • necrosis of the heart muscle with myocardial infarction,
  • fluid loss with heavy bleeding, vomiting, diarrhea.

In these cases, the degree of increase in the indicator serves as a marker of the size of the pathological focus, the depth of necrosis.

With massive burns, muscle breakdown occurs, fluid loss

Impaired renal function can only be discussed with a simultaneous increase in creatinine and a decrease in filtration in urinalysis (red blood cells, protein).

The kidneys have a significant supply of tissue and even with damage to part of the organ do not affect health.

Therefore, the toxic effect of drugs (antibiotics, anti-inflammatory and antipyretic drugs) does not appear immediately and only with an increase in creatinine.

  1. Acute renal failure can occur when poisoning with toxic substances. A person is concerned about nausea, vomiting, drowsiness. Discharged urine, swelling on the face.
  2. Chronic renal failure is the result of prolonged inflammatory kidney disease. Symptoms increase gradually: headaches, hypertension, weakness, and nausea are characteristic.

As one of the pathological reasons, thyrotoxicosis, a significant increase in thyroid function, should be indicated. Hormones can destroy muscles, cause significant weight loss.

When there is a decrease in creatinine

Low creatinine can be found in vegetarians, in pregnant women. In the first case, this is caused by a lack of animal protein in food and leads to muscle weakness with subsequent atrophy.

In pregnancy, it wears a physiological mechanism due to an adaptive increase in the total blood volume.

Measures That Can Reduce Creatinine

Depending on the reasons, it is necessary to rationally approach the choice of preventive measures or treatment.

For athletes and fond of diets, it is enough to explain the harmful nature of the chosen path, to show the effect on further changes in the body, the health forecast.

A healthy diet is easy and inexpensive to follow.

To reduce creatinine, it is enough to switch to a balanced diet with up to two liters of liquid, reduce the amount of meat products to 0.2 kg per day, but increase the consumption of fish, dairy products, cereals, fruits and vegetables.

It will require the removal of toxic drugs, anabolic hormones.

Creatinine can be reduced as an indicator of renal failure or traumatization of the body only with the help of special treatment aimed at restoring the patency of the renal tubules, normalizing blood flow, closing the burn surface, and eliminating the state of shock.

Thyrotoxicosis requires drugs that suppress excessive thyroid function.

Prevention

Unfortunately, the modern cult of the figure sets the task of explaining the harmfulness of diets, excessive physical exertion. Not every organism will endure such stressful conditions. And any diet is an additional stress with all possible consequences.

You need to go in for sports only taking into account the reserves of your body. Observe a sports doctor. Perform a regular examination. Do not use unverified dietary supplements.

Watch the video: WHAT IS CREATININE, BUN, AND GFR!! KIDNEY TERMINOLOGY! DEALING WITH KIDNEY DISEASE! (February 2020).